DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication

A Fullam, M Schröder - Biochimica et Biophysica Acta (BBA)-Gene …, 2013 - Elsevier
Traditional functions of DExD/H-box helicases are concerned with RNA metabolism; they
have been shown to play a part in nearly every cellular process that involves RNA. On the …

DEAD-box helicases: sensors, regulators, and effectors for antiviral defense

F Taschuk, S Cherry - Viruses, 2020 - mdpi.com
DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to
the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family …

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

P Sakornsakolpat, D Prokopenko, M Lamontagne… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …

Atmospheric gas plasma–induced ROS production activates TNF-ASK1 pathway for the induction of melanoma cancer cell apoptosis

M Ishaq, S Kumar, H Varinli, ZJ Han… - Molecular biology of …, 2014 - Am Soc Cell Biol
Atmospheric gas plasmas (AGPs) are able to selectively induce apoptosis in cancer cells,
offering a promising alternative to conventional therapies that have unwanted side effects …

Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival

MC Beker, B Caglayan, AB Caglayan, T Kelestemur… - Scientific reports, 2019 - nature.com
The circadian rhythm is driven by a master clock within the suprachiasmatic nucleus which
regulates the rhythmic secretion of melatonin. Bmal1 coordinates the rhythmic expression of …

DExD/H-box helicases: multifunctional regulators in antiviral innate immunity

C Su, Y Tang, C Zheng - Cellular and Molecular Life Sciences, 2022 - Springer
DExD/H-box helicases play critical roles in multiple cellular processes, including
transcription, cellular RNA metabolism, translation, and infections. Several seminal studies …

Structure and function of the SPRY/B30. 2 domain proteins involved in innate immunity

AA D'Cruz, JJ Babon, RS Norton, NA Nicola… - Protein …, 2013 - Wiley Online Library
The SPRY domain is a protein interaction module found in 77 murine and∼ 100 human
proteins, and is implicated in important biological pathways, including those that regulate …

[HTML][HTML] Atmospheric pressure gas plasma-induced colorectal cancer cell death is mediated by Nox2–ASK1 apoptosis pathways and oxidative stress is mitigated by …

M Ishaq, MDM Evans, KK Ostrikov - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Atmospheric pressure gas plasma (AGP) generates reactive oxygen species (ROS) that
induce apoptosis in cultured cancer cells. The majority of cancer cells develop a ROS …

Carvacrol, Thymol, and Garlic Essential Oil Promote Skin Innate Immunity in Gilthead Seabream (Sparus aurata) Through the Multifactorial Modulation of the …

JP Firmino, L Fernández-Alacid… - Frontiers in …, 2021 - frontiersin.org
One of the main targets for the use of phytogenics in aquafeeds is the mucosal tissues as
they constitute a physical and biochemical shield against environmental and pathogenic …

DEAD-box RNA helicases: The driving forces behind RNA metabolism at the crossroad of viral replication and antiviral innate immunity

MAM Ali - Virus Research, 2021 - Elsevier
DEAD-box RNA helicases, the largest family of superfamily 2 helicases, are a profoundly
conserved family of RNA-binding proteins, containing a distinctive Asp–Glu–Ala–Asp …