Hepatitis C virus (HCV) replication requires annealing of a liver specific microRNA, miR-122
to 2 sites on 5′ untranslated region (UTR). While, microRNAs downregulate gene …

Non-alcoholic fatty liver disease (NAFLD) is defined as a pathologic accumulation of fat in
the form of triglycerides (TG) in the liver (steatosis) that is not caused by alcohol. A subgroup …

We demonstrate that both Hepatitis C virus (HCV) and Bovine Viral Diarrhea virus (BVDV)
contain regions in their 5'UTRs that stall and repress the enzymatic activity of the cellular 5' …

While viral replication processes are largely understood, comparably little is known on
cellular mechanisms degrading viral RNA. Some viral RNAs bear a 5′-triphosphate (PPP-) …

Hepatitis C virus (HCV) recruits two molecules of the liver-specific microRNA-122 (miR-122)
to the 5′ end of its genome. This interaction promotes viral RNA accumulation, but the …

Annealing of the liver-specific microRNA, miR-122, to the Hepatitis C virus (HCV) 5′ UTR is
required for efficient virus replication. By using siRNAs to pressure escape mutations, 30 …

Hepatitis C virus (HCV) preferentially replicates in the human liver and frequently causes
chronic infection, often leading to cirrhosis and liver cancer. HCV is an enveloped virus …

Numerous post‐transcriptional RNA processes play a major role in regulating the quantity,
quality and diversity of gene expression in the cell. These include RNA processing events …

MicroRNAs (miRNAs) control gene expression at the post-transcriptional level. However, the
identification of miRNAs regulating the fate of a specific messenger RNA remains limited …

Hepatitis C virus (HCV) replication requires annealing of a liver specific small-RNA, miR-122
to 2 sites on 5′ untranslated region (UTR). Annealing has been reported to (a) stabilize the …