Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and
extensively studied neurotrophins in the mammalian brain. Among its prominent functions …

Despite years of research, epilepsy remains a poorly understood disorder. In the past
several years, work has been conducted on a variety of projects with the goal of better …

Mesenchymal stem cells (MSCs) obtained from bone marrow (BM) have been shown to
promote neuronal growth and survival. However, the comparative effects of MSCs of …

Haploinsufficiency of ANKRD11 due to deletion or truncation mutations causes KBG
syndrome, a rare genetic disorder characterized by intellectual disability, autism spectrum …

Nitric oxide (NO) has been long recognized as an important modulator of neural plasticity,
but characterization of the molecular mechanisms involved-specially the guanylyl cyclase …

Compared with other stem cells, human induced pluripotent stem cells-derived neural
progenitor cells (iPSC-NPCs) are more similar to cortical neurons in morphology and …

Nitric oxide is a gaseous neuromodulator that displays a core role in several neuronal
processes. Beyond regulating the release of neurotransmitters, nitric oxide also plays a role …

Activation of purinergic receptors by ATP (P2R) modulates glutamate release and the
activation of post-synaptic P2R is speculated to induce nitric oxide (NO) synthesis. Increased …

Nitric oxide exerts important regulatory functions in various brain processes. Its synthesis in
neurons has been most commonly ascribed to the neuronal nitric oxide synthase (nNOS) …

Cell death by glutamate excitotoxicity, mediated by N-methyl-d-aspartate (NMDA) receptors,
negatively impacts brain function, including but not limited to hippocampal neurons. The NF …