Distance distributions between paramagnetic centers in the range of 1.8 to 6 nm in
membrane proteins and up to 10 nm in deuterated soluble proteins can be measured by the …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

Parkinson's disease is a progressive neuropathological disorder that belongs to the class of
synucleinopathies, in which the protein alpha-synuclein is found at abnormally high …

The protein α-synuclein is the main component of Lewy bodies, the neuron-associated
aggregates seen in Parkinson disease and other neurodegenerative pathologies. An 11 …

Aggregation of human α-synuclein (αSyn) is linked to Parkinson's disease (PD) pathology.
The central region of the αSyn sequence contains the non-amyloid β-component (NAC) …

Abstract α-synuclein (αS) is a protein involved in neurotransmitter release in presynaptic
terminals, and whose aberrant aggregation is associated with Parkinson's disease. In …

Abstract The Protein Ensemble Database (PED)(URL: https://proteinensemble. org) is the
primary resource for depositing structural ensembles of intrinsically disordered proteins. This …

Abstract α-synuclein (αS) is an intrinsically disordered protein whose fibrillar aggregates are
the major constituents of Lewy bodies in Parkinson's disease. Although the specific function …

Parkinson's disease (PD) is an insidious and incurable neurodegenerative disease, and
represents a significant cost to individuals, carers, and ageing societies. It is defined at post …

Intrinsically disordered proteins (IDPs) or intrinsically disordered regions do not have a fixed
tertiary structure but play key roles in signal regulation, molecule recognition, and drug …