Targeting amino acid metabolism of Mycobacterium tuberculosis for developing inhibitors to curtail its survival
SD Yelamanchi, A Surolia - IUBMB life, 2021 - Wiley Online Library
Tuberculosis caused by the bacterium, Mycobacterium tuberculosis (Mtb), continues to
remain one of the most devastating infectious diseases afflicting humans. Although there are …
remain one of the most devastating infectious diseases afflicting humans. Although there are …
De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation
Intracellular pathogens including Mycobacterium tuberculosis (Mtb) have evolved with
strategies to uptake amino acids from host cells to fulfil their metabolic requirements …
strategies to uptake amino acids from host cells to fulfil their metabolic requirements …
Amino Acid Biosynthesis Inhibitors in Tuberculosis Drug Discovery
M Guida, C Tammaro, M Quaranta, B Salvucci, M Biava… - Pharmaceutics, 2024 - mdpi.com
According to the latest World Health Organization (WHO) report, an estimated 10.6 million
people were diagnosed with tuberculosis (TB) in 2022, and 1.30 million died. A major …
people were diagnosed with tuberculosis (TB) in 2022, and 1.30 million died. A major …
Improving enzyme functional annotation by integrating in vitro and in silico approaches: The example of histidinol phosphate phosphatases
T Kinateder, C Mayer, J Nazet, R Sterner - Protein Science, 2024 - Wiley Online Library
Advances in sequencing technologies have led to a rapid growth of public protein sequence
databases, whereby the fraction of proteins with experimentally verified function …
databases, whereby the fraction of proteins with experimentally verified function …
Repurposing of FDA approved drugs against uropathogenic Escherichia coli: In silico, in vitro, and in vivo analysis
Urinary tract infections (UTIs) are a serious health concern worldwide. Treatment of UTIs is
becoming a challenge as uropathogenic Escherichia coli (UPEC), which is the most …
becoming a challenge as uropathogenic Escherichia coli (UPEC), which is the most …
Experimental and computational analysis of the ancestry of an evolutionary young enzyme from histidine biosynthesis
T Kinateder, L Drexler, K Straub, R Merkl… - Protein …, 2023 - Wiley Online Library
The conservation of fold and chemistry of the enzymes associated with histidine
biosynthesis suggests that this pathway evolved prior to the diversification of Bacteria …
biosynthesis suggests that this pathway evolved prior to the diversification of Bacteria …
Characterization of a triazole scaffold compound as an inhibitor of Mycobacterium tuberculosis imidazoleglycerol‐phosphate dehydratase
D Kumar, B Jha, I Bhatia, A Ashraf… - Proteins: Structure …, 2022 - Wiley Online Library
Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), employs
ten enzymes including imidazoleglycerol‐phosphate dehydratase (IGPD) for de novo …
ten enzymes including imidazoleglycerol‐phosphate dehydratase (IGPD) for de novo …
Targeting histidinol-phosphate aminotransferase in Acinetobacter baumannii with salvianolic acid B: A structure-based approach to novel antibacterial strategies
A Singh, M Tanwar, TP Singh, S Sharma… - Archives of Biochemistry …, 2025 - Elsevier
Undoubtedly, Acinetobacter baumannii is a major ESKAPE pathogen that poses a
significant threat to public health, causing severe nosocomial infections with high mortality …
significant threat to public health, causing severe nosocomial infections with high mortality …
Identification of novel inhibitors against Escherichia coli utilizing HisC as a target from histidine biosynthesis pathway
Escherichia coli is a gram-negative bacterial pathogen that poses a significant challenge
both clinically and epidemiologically. Large numbers of multi-drug resistant E. coli have …
both clinically and epidemiologically. Large numbers of multi-drug resistant E. coli have …
In Vitro and In Vivo Studies of Heraclenol as a Novel Bacterial Histidine Biosynthesis Inhibitor against Invasive and Biofilm-Forming Uropathogenic Escherichia coli
H Kaur, N Chaudhary, V Modgil, M Kalia, V Kant… - Antibiotics, 2023 - mdpi.com
Globally, urinary tract infections (UTIs) are one of the most frequent bacterial infections.
Uropathogenic Escherichia coli (UPEC) are the predominant etiological agents causing …
Uropathogenic Escherichia coli (UPEC) are the predominant etiological agents causing …