Regulatory R-loops as facilitators of gene expression and genome stability
C Niehrs, B Luke - Nature reviews Molecular cell biology, 2020 - nature.com
R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …
during transcription. R-loop misregulation is associated with DNA damage, transcription …
Chromosome Duplication in Saccharomyces cerevisiae
SP Bell, K Labib - Genetics, 2016 - academic.oup.com
The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …
Eukaryotic mismatch repair in relation to DNA replication
TA Kunkel, DA Erie - Annual review of genetics, 2015 - annualreviews.org
Three processes act in series to accurately replicate the eukaryotic nuclear genome. The
major replicative DNA polymerases strongly prevent mismatch formation, occasional …
major replicative DNA polymerases strongly prevent mismatch formation, occasional …
Mismatch repair
The concept of mismatch repair (MMR) was formulated independently in 1964 to explain the
removal of brominated nucleotides from DNA as well as gene conversion during genetic …
removal of brominated nucleotides from DNA as well as gene conversion during genetic …
[HTML][HTML] Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development
The presence of ribonucleotides in genomic DNA is undesirable given their increased
susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process …
susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process …
Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy
K Bartsch, K Knittler, C Borowski… - Human molecular …, 2017 - academic.oup.com
Hypomorphic mutations in the DNA repair enzyme RNase H2 cause the neuroinflammatory
autoimmune disorder Aicardi-Goutières syndrome (AGS). Endogenous nucleic acids are …
autoimmune disorder Aicardi-Goutières syndrome (AGS). Endogenous nucleic acids are …
Eukaryotic DNA replication fork
PMJ Burgers, TA Kunkel - Annual review of biochemistry, 2017 - annualreviews.org
This review focuses on the biogenesis and composition of the eukaryotic DNA replication
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …
[HTML][HTML] RNase H1 and H2 are differentially regulated to process RNA-DNA hybrids
A Lockhart, VB Pires, F Bento, V Kellner, S Luke-Glaser… - Cell reports, 2019 - cell.com
RNA-DNA hybrids are tightly regulated to ensure genome integrity. The RNase H enzymes
RNase H1 and H2 contribute to chromosomal stability through the removal of RNA-DNA …
RNase H1 and H2 contribute to chromosomal stability through the removal of RNA-DNA …
DNA mismatch repair and its many roles in eukaryotic cells
D Liu, G Keijzers, LJ Rasmussen - Mutation Research/Reviews in Mutation …, 2017 - Elsevier
DNA mismatch repair (MMR) is an important DNA repair pathway that plays critical roles in
DNA replication fidelity, mutation avoidance and genome stability, all of which contribute …
DNA replication fidelity, mutation avoidance and genome stability, all of which contribute …
RNases H: Structure and mechanism
M Hyjek, M Figiel, M Nowotny - DNA repair, 2019 - Elsevier
RNases H are a family of endonucleases that hydrolyze RNA residues in various nucleic
acids. These enzymes are present in all branches of life, and their counterpart domains are …
acids. These enzymes are present in all branches of life, and their counterpart domains are …