Clinical update: cardiovascular disease in diabetes mellitus: atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus–mechanisms …

CC Low Wang, CN Hess, WR Hiatt, AB Goldfine - Circulation, 2016 - Am Heart Assoc
Cardiovascular disease remains the principal cause of death and disability among patients
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …

Oxidative stress and new pathogenetic mechanisms in endothelial dysfunction: potential diagnostic biomarkers and therapeutic targets

MG Scioli, G Storti, F D'Amico… - Journal of Clinical …, 2020 - mdpi.com
Cardiovascular diseases (CVD), including heart and pathological circulatory conditions, are
the world's leading cause of mortality and morbidity. Endothelial dysfunction involved in …

[HTML][HTML] Luteolin protects against diabetic cardiomyopathy by inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses

L Li, W Luo, Y Qian, W Zhu, J Qian, J Li, Y Jin, X Xu… - Phytomedicine, 2019 - Elsevier
Background Diabetes mellitus is a well-known risk factor for the development of heart failure.
Inflammation and oxidative stress play a key role in the development of diabetic …

Pathophysiology of coronary microvascular dysfunction

F Crea, RA Montone, R Rinaldi - Circulation Journal, 2022 - jstage.jst.go.jp
Ischemic heart disease (IHD) is commonly recognized as the consequence of coronary
atherosclerosis and obstructive coronary artery disease (CAD). However, a significant …

Direct cardiac actions of sodium glucose cotransporter 2 inhibitors target pathogenic mechanisms underlying heart failure in diabetic patients

L Uthman, A Baartscheer, CA Schumacher… - Frontiers in …, 2018 - frontiersin.org
Sodium glucose cotransporter 2 inhibitors (SGLT2i) are the first antidiabetic compounds that
effectively reduce heart failure hospitalization and cardiovascular death in type 2 diabetics …

[HTML][HTML] Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy

ZV Varga, Z Giricz, L Liaudet, G Haskó… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Diabetes is a recognized risk factor for cardiovascular diseases and heart failure. Diabetic
cardiovascular dysfunction also underscores the development of diabetic retinopathy …

MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy

X Li, N Du, Q Zhang, J Li, X Chen, X Liu, Y Hu… - Cell death & …, 2014 - nature.com
Diabetic cardiomyopathy is a common cardiac condition in patients with diabetes mellitus,
which can result in cardiac hypertrophy and subsequent heart failure, associated with …

Emergence of SGLT2 inhibitors as powerful antioxidants in human diseases

KF Tsai, YL Chen, TTY Chiou, TH Chu, LC Li, HY Ng… - Antioxidants, 2021 - mdpi.com
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral glucose-lowering
agents. Apart from their glucose-lowering effects, large clinical trials assessing certain …

Coronary microvascular dysfunction in diabetes mellitus

A Kibel, K Selthofer-Relatic… - Journal of …, 2017 - journals.sagepub.com
The significance, mechanisms and consequences of coronary microvascular dysfunction
associated with diabetes mellitus are topics into which we have insufficient insight at this …

Andrographolide protects against HG‐induced inflammation, apoptosis, migration, and impairment of angiogenesis via PI3K/AKT‐eNOS signalling in HUVECs

MX Duan, H Zhou, QQ Wu, C Liu, Y Xiao… - Mediators of …, 2019 - Wiley Online Library
Andrographolide (Andr) is a major component isolated from the plant Andrographis
paniculata. Inflammation, apoptosis, and impaired angiogenesis are implicated in the …