Hyperlipidemia is a major risk factor for cardiovascular morbidity and mortality. Statins are
the first-choice therapy for dyslipidemias and are considered the cornerstone of …

Although statins are effective for treating hypercholesterolemia, they can have various side
effects, including rhabdomyolysis, a potentially fatal condition. This review evaluated the …

Aims: We have shown that autophagy and mitophagy are required for preconditioning. While
statin's cardioprotective effects are well known, the role of autophagy/mitophagy in statin …

Vascular oxidative stress is a key feature of atherogenesis, and targeting vascular redox
signalling is a rational therapeutic goal in vascular disease pathogenesis. 3-hydroxy-3 …

Statins, a group of drugs used for the treatment of hypercholesterolemia, have adverse
effects on skeletal muscle. The symptoms of these effects range from slight myalgia to …

Cholesterol regulates numerous cellular processes. Depleting its synthesis in skeletal
myofibers induces vacuolization and contraction impairment. However, little is known about …

Highlights•Necrotic cell death induces inflammation with inflammasome activation.•
Inflammasome activation precedes pyroptosis, which is also an inflammatory cell …

Preterm birth (PTB), the leading cause of neonatal morbidity and mortality, urgently requires
novel therapeutic agents. Spontaneous PTB, resulting from preterm labor, is commonly …

Addressing the factors which lead to the development of statin-associated muscle symptoms
(SAMS) is vital for maintaining patient compliance with these pharmaceuticals, and thus …

The goal of this study was to integrate systems pharmacology and biochemical flux to
delineate drug-induced rhabdomyolysis by leveraging prior knowledge and publicly …