Reciprocal interactions between epithelium and mesenchyme mediate crucial aspects of
embryonic development and direct the coordinated organogenesis, correct spatial …

The majority of breast cancer research is conducted using established breast cancer cell
lines as in vitro models. An alternative is to use cultures established from primary breast …

Human breast tumours are diverse in their natural history and in their responsiveness to
treatments. Variation in transcriptional programs accounts for much of the biological diversity …

Breast cancer is the most common cancer in women and a leading cause of cancer-related
deaths for women worldwide. Various cell models have been developed to study breast …

Sample damage by X-rays and other radiation limits the resolution of structural studies on
non-repetitive and non-reproducible structures such as individual biomolecules or cells …

Normal human breast epithelial cells show a high degree of phenotypic plasticity in
monolayer culture and express many traits that otherwise characterize tumor cells in vivo …

Controversy surrounds reports describing the derivation of human trophoblast cells from
placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers …

The MCF10 series of cell lines was derived from benign breast tissue from a woman with
fibrocystic disease. The MCF10 human breast epithelial model system consists of mortal …

The epithelial compartment of the human breast comprises two distinct lineages: the luminal
epithelial and the myoepithelial lineage. We have shown previously that a subset of the …

Senescence and genomic integrity are thought to be important barriers in the development
of malignant lesions. Human fibroblasts undergo a limited number of cell divisions before …