Resilience is the ability to cope with critical situations through the use of personal and
socially mediated resources. Since a lack of resilience increases the risk of developing …

In early 1920s, tyramine oxidase was discovered that metabolized tyramine and in 1933
Blaschko demonstrated that this enzyme also metabolized adrenaline, noradrenaline and …

Monoamine oxidase (MAO) catalyzes the oxidative deamination of monoamine
neurotransmitters and dietary amines. Two pharmacological types with different substrate …

Epigenetic processes such as DNA methylation are considered key mechanisms at the
crossroads between genetics and environment in the etiology of mental disorders. The …

Most people will experience a traumatic event within their lifetime. One commonly
recognized response to trauma exposure is posttraumatic stress disorder (PTSD). The …

Pharmacotherapy for neuropsychiatric disorders, such as anxiety and depression, has been
characterized by significant inter-individual variability in drug response and the development …

Background Epigenetic markers such as DNA methylation of the monoamine oxidase A
(MAOA) gene have previously been shown to be altered in anxiety-and stress-related …

Fear conditioning and avoidance tasks usually elicit adaptive aversive memories. Traumatic
memories are more intense, generalized, inflexible, and resistant to attenuation via …

Background The serotonin transporter gene (SLC6A4; 5-HTT; SERT) is considered a prime
candidate in pharmacogenetic research in major depressive disorder (MDD). Besides …

There is evidence that plasma cortisol concentration can be either increased or decreased
in patients with depression and related anxiety and stress-related disorders; the exact …