Chronic kidney disease as oxidative stress-and inflammatory-mediated cardiovascular disease

A Podkowińska, D Formanowicz - Antioxidants, 2020 - mdpi.com
Generating reactive oxygen species (ROS) is necessary for both physiology and pathology.
An imbalance between endogenous oxidants and antioxidants causes oxidative stress …

Common and novel markers for measuring inflammation and oxidative stress ex vivo in research and clinical practice—which to use regarding disease outcomes?

A Menzel, H Samouda, F Dohet, S Loap, MS Ellulu… - Antioxidants, 2021 - mdpi.com
Many chronic conditions such as cancer, chronic obstructive pulmonary disease, type-2
diabetes, obesity, peripheral/coronary artery disease and auto-immune diseases are …

Gender differences in diabetic kidney disease: focus on hormonal, genetic and clinical factors

A Giandalia, AE Giuffrida, G Gembillo… - International journal of …, 2021 - mdpi.com
Diabetic kidney disease (DKD) is one of the most serious complications of both type 1
(T1DM) and type 2 diabetes mellitus (T2DM). Current guidelines recommend a personalized …

Kidney disease in diabetic patients: from pathophysiology to pharmacological aspects with a focus on therapeutic inertia

G Gembillo, Y Ingrasciotta, S Crisafulli, N Luxi… - International journal of …, 2021 - mdpi.com
Diabetes mellitus represents a growing concern, both for public economy and global health.
In fact, it can lead to insidious macrovascular and microvascular complications, impacting …

Diabetic nephropathy: significance of determining oxidative stress and opportunities for antioxidant therapies

M Darenskaya, S Kolesnikov, N Semenova… - International Journal of …, 2023 - mdpi.com
Diabetes mellitus (DM) belongs to the category of socially significant diseases with epidemic
rates of increases in prevalence. Diabetic nephropathy (DN) is a specific kind of kidney …

Role of sex hormones in prevalent kidney diseases

C Conte, G Antonelli, ME Melica, M Tarocchi… - International Journal of …, 2023 - mdpi.com
Chronic kidney disease (CKD) is a constantly growing global health burden, with more than
840 million people affected worldwide. CKD presents sex disparities in the pathophysiology …

Cardiorenal syndrome: new pathways and novel biomarkers

G Gembillo, L Visconti, MA Giusti, R Siligato, A Gallo… - Biomolecules, 2021 - mdpi.com
Cardiorenal syndrome (CRS) is a multi-organ disease characterized by the complex
interaction between heart and kidney during acute or chronic injury. The pathogenesis of …

The aggressive diabetic kidney disease in youth-onset type 2 diabetes: pathogenetic mechanisms and potential therapies

M Amatruda, G Gembillo, AE Giuffrida, D Santoro… - Medicina, 2021 - mdpi.com
Youth-onset Type 2 Diabetes Mellitus (T2DM) represents a major burden worldwide. In the
last decades, the prevalence of T2DM became higher than that of Type 1 Diabetes Mellitus …

The emerging role of vitamin D and vitamin D receptor in diabetic nephropathy

M Lei, Z Liu, J Guo - BioMed research international, 2020 - Wiley Online Library
Diabetic nephropathy (DN), one of the most common and severe microvascular
complications of diabetes mellitus (DM), is an important risk factor for DM patient's death …

Increased expression of circulating stress markers, inflammatory cytokines and decreased antioxidant level in diabetic nephropathy

G Mansoor, M Tahir, T Maqbool, SQ Abbasi, F Hadi… - Medicina, 2022 - mdpi.com
Background and Objectives: The main objective of the present study was to determine the
role of oxidative markers (glutathione (GSH), advanced oxidation protein products (AOPP) …