Tribbles in the 21st century: the evolving roles of tribbles pseudokinases in biology and disease
The Tribbles (TRIB) pseudokinases control multiple aspects of eukaryotic cell biology and
evolved unique features distinguishing them from all other protein kinases. The atypical …
evolved unique features distinguishing them from all other protein kinases. The atypical …
[HTML][HTML] Understanding protein–drug interactions using ion mobility–mass spectrometry
CE Eyers, M Vonderach, S Ferries, K Jeacock… - Current opinion in …, 2018 - Elsevier
Ion mobility–mass spectrometry (IM–MS) is an important addition to the analytical toolbox for
the structural evaluation of proteins, and is enhancing many areas of biophysical analysis …
the structural evaluation of proteins, and is enhancing many areas of biophysical analysis …
Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity
Reactive oxygen species (ROS) are physiological mediators of cellular signaling and play
potentially damaging roles in human diseases. In this study, we found that the catalytic …
potentially damaging roles in human diseases. In this study, we found that the catalytic …
Tracing the origin and evolution of pseudokinases across the tree of life
Protein phosphorylation by eukaryotic protein kinases (ePKs) is a fundamental mechanism
of cell signaling in all organisms. In model vertebrates,~ 10% of ePKs are classified as …
of cell signaling in all organisms. In model vertebrates,~ 10% of ePKs are classified as …
Custom workflow for the confident identification of sulfotyrosine-containing peptides and their discrimination from phosphopeptides
Protein tyrosine sulfation (sY) is a post-translational modification (PTM) catalyzed by Golgi-
resident tyrosyl protein sulfo transferases (TPSTs). Information on sY in humans is currently …
resident tyrosyl protein sulfo transferases (TPSTs). Information on sY in humans is currently …
cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility–mass spectrometry
DP Byrne, M Vonderach, S Ferries… - Biochemical …, 2016 - portlandpress.com
cAMP-dependent protein kinase (PKA) is an archetypal biological signaling module and a
model for understanding the regulation of protein kinases. In the present study, we combine …
model for understanding the regulation of protein kinases. In the present study, we combine …
Cataloguing the dead: breathing new life into pseudokinase research
Pseudoenzymes are present within many, but not all, known enzyme families and lack one
or more conserved canonical amino acids that help define their catalytically active …
or more conserved canonical amino acids that help define their catalytically active …
Evolution of functional diversity in the holozoan tyrosine kinome
The emergence of multicellularity is strongly correlated with the expansion of tyrosine
kinases, a conserved family of signaling enzymes that regulates pathways essential for cell …
kinases, a conserved family of signaling enzymes that regulates pathways essential for cell …
Potts Hamiltonian Models and Molecular Dynamics Free Energy Simulations for Predicting the Impact of Mutations on Protein Kinase Stability
Single-point mutations in kinase proteins can affect their stability and fitness, and
computational analysis of these effects can provide insights into the relationships among …
computational analysis of these effects can provide insights into the relationships among …
A resource for exploring the understudied human kinome for research and therapeutic opportunities
The functions of protein kinases have been widely studied and over 60 kinase inhibitors are
FDA-approved drugs. Membership in the human kinome is nonetheless subject to multiple …
FDA-approved drugs. Membership in the human kinome is nonetheless subject to multiple …