Type 2 diabetes mellitus (T2DM) is an increasingly prevalent multifactorial disease that has
both genetic and environmental risk factors, resulting in impaired glucose homeostasis …

The solute carrier (SLC) superfamily comprises more than 400 transport proteins mediating
the influx and efflux of substances such as ions, nucleotides, and sugars across biological …

Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals …

We performed collapsing analyses on 454,796 UK Biobank (UKB) exomes to detect gene-
level associations with diabetes. Recessive carriers of nonsynonymous variants in …

The glucagon-like peptide-1 receptor (GLP1R) is a class BG protein-coupled receptor
(GPCR) involved in metabolism. Presently, its visualization is limited to genetic …

Human embryonic stem cell-derived β cells (SC-β cells) hold great promise for treatment of
diabetes, yet how to achieve functional maturation and protect them against metabolic …

A rare loss-of-function allele p. Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8),
which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited …

Abstract Type 2 diabetes (T2D) is associated with β-cell dedifferentiation. Aldehyde
dehydrogenase 1 isoform A3 (ALHD1A3) is a marker of β-cell dedifferentiation and …

Abstract Purpose of Review Type 2 diabetes (T2D), which accounts for the vast majority of
diabetes cases, is essentially a diagnosis of exclusion in current clinical practice. Therefore …

Type 1 diabetes mellitus (T1DM) is an autoimmune disease caused by the destruction of
pancreatic beta cells, in which immune system disorder plays an important role. Finding a …