Background Clinical research affecting how doctors practice medicine is increasingly
sponsored by companies that make drugs and medical devices. Previous systematic …

Background We performed a systematic review to assess whether we can quantify the
underreporting of adverse events (AEs) in the published medical literature documenting the …

Randomised controlled trials remain the reference standard for healthcare research on
effects of interventions, and the need to report both benefits and harms is essential. The …

Objectives To reanalyse SmithKline Beecham's Study 329 (published by Keller and
colleagues in 2001), the primary objective of which was to compare the efficacy and safety of …

Objectives To investigate whether the conclusion of a recent systematic review and network
meta-analysis (Cipriani et al) that antidepressants are more efficacious than placebo for …

Background: It is unclear whether antidepressants can prevent suicides or suicide attempts,
particularly during long-term use. Methods: We carried out a comprehensive review of long …

Background There is ongoing controversy whether antidepressant use alters suicide risk in
adults with depression and other treatment indications. Methods Systematic review of …

The United States Food and Drug Administration issued a Black Box warning in October
2004 after placebo-controlled trials of antidepressant medications found an increased risk of …

Objective To quantify the risk of suicidality and violence when selective serotonin and
serotonin-norepinephrine reuptake inhibitors are given to adult healthy volunteers with no …

Randomized controlled trials remain the reference standard for healthcare research on
effects of interventions, and the need to report both benefits and harms is essential. The …