Bloodstream infection (BSI) is defined by positive blood cultures in a patient with systemic
signs of infection and may be either secondary to a documented source or primary—that is …

Bacterial infections, caused predominately by Gram-positive and Gram-negative organisms,
are proliferation of harmful strains of bacteria on or inside the body. Hospital-acquired and …

The rise of drug-resistance has made the deserted clinical requirement to improve of new
classes of antibiotics agents. The development of antibacterial agents with the novel method …

Extended spectrum β-lactamase (ESBL)-producing bacteria are prevalent worldwide and
correlated with hospital infections, but they have been evolving as an increasing cause of …

Antimicrobial de-escalation (ADE) is defined as the discontinuation of one or more
components of combination empirical therapy, and/or the change from a broad-spectrum to …

The composition of the gut microbiota is highly dynamic and changes according to various
conditions. The gut microbiota mainly includes difficult-to-cultivate anaerobic bacteria, hence …

Background Healthcare-associated infections involving Gram-negative bacteria (GNB) with
difficult-to-treat resistance (DTR) phenotype are associated with impaired patient-centered …

Antibiotic resistance is a major health problem and will be probably one of the leading
causes of deaths in the coming years. One of the most effective ways to fight against …

Enterobacter hormaechei is involved in multiple hospital-associated infections and is
resistant to beta-lactam and tetracycline antibiotics. Due to emerging antibiotics resistance in …

Background Use of third-generation cephalosporins, such as cefotaxime, is associated with
an increased risk of selection for antimicrobial resistance, so alternative antibiotics need to …