We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …

Background We report on the long term outcome of the EORTC 18952 adjuvant interferon
(IFN) trial in 1388 resected stage IIB/III melanoma patients and identify key predictive factors …

The development and progression of cancer, a collection of diseases with complex genetic
architectures, is facilitated by the interplay of multiple etiological factors. This complexity …

Existing clinical, anatomopathological and molecular biomarkers fail to reliably predict the
prognosis of cutaneous melanoma. Biomarkers for determining which patients receive …

Background Utrophin (UTRN), as a tumor suppressor gene, is involved in various cancer
progression. The function of UTRN in the melanoma process and the related molecular …

Simple Summary Goats are important domestic animals that provide meat, milk, fur, and
other products for humans. The demand for these products has increased in recent years …

Selective inhibition of the mutant BRAF protein is a highly promising therapeutic approach
for melanoma patients carrying the BRAF V600E mutation. Despite the remarkable clinical …

Background Primary melanoma ulceration is an unfavourable prognostic factor included in
current staging systems. Yet, the immunological and molecular alterations responsible for …

A large variety of molecular pathways in melanoma progression suggests that no individual
molecular alteration is crucial in itself. Our aim was to define the molecular alterations …

Ulceration of primary melanomas is associated with poor prognosis yet is reported to predict
benefit from adjuvant interferon. To better understand the biological processes involved …