Eukaryotic mRNA decapping activation
E Vidya, TF Duchaine - Frontiers in Genetics, 2022 - frontiersin.org
The 5′-terminal cap is a fundamental determinant of eukaryotic gene expression which
facilitates cap-dependent translation and protects mRNAs from exonucleolytic degradation …
facilitates cap-dependent translation and protects mRNAs from exonucleolytic degradation …
Eukaryotic mRNA decapping factors: molecular mechanisms and activity
F He, A Jacobson - The FEBS journal, 2023 - Wiley Online Library
Decapping is the enzymatic removal of 5′ cap structures from mRNAs in eukaryotic cells.
Cap structures normally enhance mRNA translation and stability, and their excision commits …
Cap structures normally enhance mRNA translation and stability, and their excision commits …
Dual Input-Controlled Synthetic mRNA Circuit for Bidirectional Protein Expression Regulation
Synthetic mRNA circuits manipulate cell fate by controlling output protein expression via cell-
specific input molecule detection. Most current circuits either repress or enhance output …
specific input molecule detection. Most current circuits either repress or enhance output …
miR-4293 upregulates lncRNA WFDC21P by suppressing mRNA-decapping enzyme 2 to promote lung carcinoma proliferation
Q Zhang, YF Yan, Q Lv, YJ Li, RR Wang, GB Sun… - Cell Death & …, 2021 - nature.com
Non-coding RNAs (ncRNAs) involve in diverse biological processes by post-transcriptional
regulation of gene expression. Emerging evidence shows that miRNA-4293 plays a …
regulation of gene expression. Emerging evidence shows that miRNA-4293 plays a …
Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs
In eukaryotes, 43S preinitiation complex (PIC) formation is a rate-determining step of
translation. Ribosome recycling following translation termination produces free 40S subunits …
translation. Ribosome recycling following translation termination produces free 40S subunits …
Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo
Yeast DEAD-box helicase Ded1 stimulates translation initiation, particularly of mRNAs with
structured 5'UTRs. Interactions of the Ded1 N-terminal domain (NTD) with eIF4A, and Ded1 …
structured 5'UTRs. Interactions of the Ded1 N-terminal domain (NTD) with eIF4A, and Ded1 …
mRNA decapping activators Pat1 and Dhh1 regulate transcript abundance and translation to tune cellular responses to nutrient availability
We have examined the roles of yeast mRNA decapping-activators Pat1 and Dhh1 in
repressing the translation and abundance of specific mRNAs in nutrient-replete cells using …
repressing the translation and abundance of specific mRNAs in nutrient-replete cells using …
Dcp2 C-terminal cis-binding elements control selective targeting of the decapping enzyme by forming distinct decapping complexes
F He, C Wu, A Jacobson - Elife, 2022 - elifesciences.org
A single Dcp1–Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for
decapping-dependent 5′ to 3′ decay, but the molecular mechanisms controlling mRNA …
decapping-dependent 5′ to 3′ decay, but the molecular mechanisms controlling mRNA …
Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability
Degradation of most yeast mRNAs involves decapping by Dcp1/Dcp2. DEAD-box protein
Dhh1 has been implicated as an activator of decapping, in coupling codon non-optimality to …
Dhh1 has been implicated as an activator of decapping, in coupling codon non-optimality to …
Global profiling of cellular substrates of human Dcp2
Decapping is the first committed step in 5′-to-3′ RNA decay, and in the cytoplasm of
human cells, multiple decapping enzymes regulate the stabilities of distinct subsets of …
human cells, multiple decapping enzymes regulate the stabilities of distinct subsets of …