Adult gliomas are aggressive brain tumours associated with low patient survival rates and
limited life expectancy. The most important hallmark of this type of tumour is its invasive …

The discovery of microRNAs (miRNAs) has added a new player to the regulation of gene
expression. With the increasing number of molecular species involved in gene regulatory …

Atherosclerosis, the leading death in the United State, is a disease in which a plaque builds
up inside the arteries. As the plaque continues to grow, the shear force of the blood flow …

Rationale: In some patients with type 2 diabetes mellitus (DM) without hypertension, cardiac
hypertrophy and attenuated cardiac function are observed, and this insult is termed diabetic …

Objectives: The aim of this study was to clarify the usefulness of plasma exosomal microRNA-
451a (miR-451a) as a novel biomarker for the early prediction of recurrence and prognosis …

Individual cells within an otherwise genetically homogenous population constantly undergo
fluctuations in their molecular state, giving rise to non-genetic heterogeneity. Such diversity …

Glioblastoma multiforme (GBM) is an aggressive grade IV astrocytoma with a 1-year median
survival rate despite current treatment modalities. A thorough understanding of the vast …

We report a mathematical model which depicts the spatiotemporal dynamics of glioma cells,
macrophages, cytotoxic-T-lymphocytes, immuno-suppressive cytokine TGF-β and immuno …

The mortality of patients with solid tumors is mostly due to metastasis that relies on the
interplay between migration and proliferation. The “go or grow” hypothesis postulates that …

Tumor cells develop different strategies to cope with changing microenvironmental
conditions. A prominent example is the adaptive phenotypic switching between cell …