Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and
represents the hepatic expression of several metabolic abnormalities of high epidemiologic …

Drug-induced liver injury (DILI) has become a leading cause of severe liver disease in
Western countries and therefore poses a major clinical and regulatory challenge. Whereas …

In this study, we investigated the molecular basis for the altered signal transduction
associated with soluble amyloid β-protein (Aβ) oligomer-mediated neurotoxicity in the …

The development of an invasive cancer involves a progressive switch from predominantly
apoptotic (scheduled) to necrotic (unscheduled) tumor cell death. This switch is associated …

Programmed cell death is necessary for homeostasis in multicellular organisms and it is also
widely recognized to occur in unicellular organisms. However, the mechanisms through …

Mitochondria are the main energy source in hepatocytes and play a major role in extensive
oxidative metabolism and normal function of the liver. This key role also assigns …

OBJECTIVE: To determine the concentration of syncytiotrophoblast-derived microparticles
(STBMs) in the maternal circulation and the rate of syncytiotrophoblast apoptosis in the …

Parkinson's disease (PD) is a common neurodegenerative disease characterised by a slow
and progressive degeneration of dopaminergic neurons in the substantia nigra (SN) …

Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the excessive
accumulation of triglycerides in hepatocytes. NAFLD is the most frequent chronic liver …