Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …

The biochemical and biophysical investigation of proteins, nucleic acids, and the assemblies
that they form yields essential information to understand complex systems. Analytical …

Transcription factors (TFs) regulate gene expression through chromatin where nucleosomes
restrict DNA access. To study how TFs bind nucleosome-occupied motifs, we focused on the …

Whole-genome sequencing data mining efforts have revealed numerous histone mutations
in a wide range of cancer types. These occur in all four core histones in both the tail and …

Nuclear proteins bind chromatin to execute and regulate genome-templated processes.
While studies of individual nucleosome interactions have suggested that an acidic patch on …

Chromatin remodeling is of crucial importance during brain development. Pathogenic
alterations of several chromatin remodeling ATPases have been implicated in …

Eukaryotes have a multitude of diverse mechanisms for organising and using their
genomes, but the histones that make up chromatin are highly conserved. Unusually …

ADP-ribosylation of nuclear proteins is a critical feature of various DNA damage repair
pathways. Histones, particularly H3 and H2B, are major targets of ADP-ribosylation and are …

Mutations of the Glu76 residue of canonical histone H2B are frequently found in cancer
cells. However, it is quite mysterious how a single amino acid substitution in one of the …

Abstract Purpose Sifrim–Hitz–Weiss syndrome (SIHIWES) is a recently described
multisystemic neurodevelopmental disorder caused by de novo variants in CHD4. In this …