For more than five decades, Southeast Asia (SEA) has been fertile ground for the
emergence of drug-resistant Plasmodium falciparum malaria. After generating parasites …

In SEA, clinical and epidemiological investigations are urgently needed to stop the further
spread of artemisinin resistance, monitor the efficacy of ACTs where K13 mutations are …

Fundamental gaps remain in our understanding of how immunity to malaria develops. We
used detailed clinical and entomological data from parallel cohort studies conducted across …

Malaria and iron deficiency (ID) are common and interrelated public health problems in
African children. Observational data suggest that interrupting malaria transmission reduces …

Malaria transmission depends on the presence of Plasmodium gametocytes that are the
only parasite life stage that can infect mosquitoes. Gametocyte production varies between …

Background The global prevalence of X-linked glucose-6-phosphate dehydrogenase
(G6PD) deficiency is thought to be a result of selection by malaria, but epidemiological …

Understanding how ABO blood group interacts with Plasmodium falciparum (P. falciparum)
infection may facilitate development of antimalarial treatments and vaccines. This study …

Humans and crown catarrhines evolved with the inability to synthesize the oligosaccharide
galactose-α-1, 3-galactose (α-Gal). In turn, they naturally produce high quantities of the …

The malaria parasite has co‐evolved with its human host as each organism struggles for
resources and survival. The scars of this war are carried in the human genome in the form of …

Plasmodium falciparum malaria causes morbidity and mortality in African children with sickle
cell anemia (SCA), but comparisons of host responses to P falciparum between children with …