Vitamin D and its' metabolites are a crucial part of the endocrine system that controls whole
body calcium homeostasis. The goal of this hormonal control is to regulate serum calcium …

Abstract Jones, Glenville, Stephen A. Strugnell, and Hector F. DeLuca. Current
Understanding of the Molecular Actions of Vitamin D. Physiol. Rev. 78: 1193–1231, 1998 …

Introduction V ITAMIN D is a seco-steroid in which the B-ring of the
cyclopentanoperhydrophenanthrene structure is cleaved. The vitamin is either obtained from …

We reported recently that suppression of the renal lα, 25‐dihyroxyvitamin D3 (lα, 25‐(OH) 2‐
D3) production in aP2‐agouti transgenic mice by increasing dietary calcium decreases …

Vitamin D3 is the precursor of the steroid hormone calcitriol (1α, 25-dihydroxyvitamin D3), a
potent agonist of the transcription factor vitamin D receptor (VDR). Calcitriol has received …

The human serum vitamin D-binding protein (DBP) has many physiologically important
functions, ranging from transporting vitamin D3 metabolites, binding and sequestering …

Introduction AN EXCITING new era has developed in the vitamin D field with the discovery of
new target tissues, mechanisms of action, and selective analogs. As a clinical counterpoint …

The steroid hormone 1 alpha, 25-dihydroxyvitamin D3 (1 alpha, 25-(OH) 2D3) generates
biological responses via both genomic and nongenomic mechanisms. This article reports …

Data from epidemiological studies has suggested that vitamin D deficiency may promote
prostate cancer, although the mechanism is not understood. We have previously …

Abstract Background: The secosteroid 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3)
actsthrough the vitamin D receptor (VDR) to elicit many activities that make it a promising …