Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …

Autotaxin is a secreted enzyme that produces most of the extracellular lysophosphatidate
from lysophosphatidylcholine, the most abundant phospholipid in blood plasma …

Lead (Pb)-induced reproductive toxicity is a well-characterized adverse effect associated
with this heavy metal. It has been found that Pb exposure is associated with altered …

Aims This study mainly evaluated the protective mechanism of histidine against the hepatic
oxidative stress after high-salt exposure (HSE) through combined analysis of non-targeted …

The present study was designed to investigate the hepatoprotective potential of dimethyl
fumarate (DMF) against thioacetamide (TAA)‐induced liver damage. Wistar rats were treated …

Aims The potential antifibrotic effects of melatonin against induced hepatic fibrosis were
explored. Main methods Rats were allocated into four groups: placebo; thioacetamide …

Metabolites are small products of metabolism that provide a snapshot of the wellbeing of an
organism and the mechanisms that control key physiological processes involved in health …

Maternal obesity programs the risk for development of nonalcoholic fatty liver disease
(NAFLD) in offspring. Maternal exercise is a potential intervention to prevent …

Infection with Schistosoma japonicum (S. japonicum) is an important zoonotic parasitic
disease that causes liver fibrosis in both human and domestic animals. The activation of …

Metabolomics offers new insights into disease mechanisms that is enhanced when adopting
orthogonal instrumental platforms to expand metabolome coverage, while also reducing …