Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

The immune system is highly complex and distributed throughout an organism, with
hundreds to thousands of cell states existing in parallel with diverse molecular pathways …

Cepharanthine is a secondary metabolite isolated from Stephania. It has been reported that
it has anti-conronaviruses activities including severe acute respiratory syndrome …

Abstract Although three-dimensional (3D) genome organization is central to many aspects of
nuclear function, it has been difficult to measure at the single-cell level. To address this, we …

Programmable genome-engineering technologies, such as CRISPR (clustered regularly
interspaced short palindromic repeats) nucleases and massively parallel CRISPR screens …

Abstract Redwood trees (Sequoioideae), including Metasequoia glyptostroboides (dawn
redwood), Sequoiadendron giganteum (giant sequoia), and Sequoia sempervirens (coast …

The spatial organization of the genome in the cell nucleus is pivotal to cell function.
However, how the 3D genome organization and its dynamics influence cellular phenotypes …

Humans show reproducible sex-differences in cognition and psychopathology that may be
contributed to by influences of gonadal sex-steroids and/or sex-chromosomes on regional …

Spatiotemporal chromatin reorganization during hematopoietic differentiation has not been
comprehensively characterized, mainly because of the large numbers of starting cells …

The hierarchical three-dimensional folding of the mammalian genome constitutes an
important regulatory layer of gene expression and cell fate control during processes such as …