• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

From the 1Mayo Clinic, Jacksonville, Florida, 2Yale University School of Medicine, New
Haven, Connecticut, 3Cleveland Clinic Lerner College of Medicine of Case Western …

Pacemakers, implantable cardiac defibrillators, and cardiac resynchronization therapy
devices are potentially life-saving treatments for a number of cardiac conditions, but are not …

LRRC4 is a novel relatively specific gene, which displays significant down-regulation in
primary brain tumor biopsies and has the potential to suppress brain tumor growth. In this …

Staphylococcus aureus is a major human pathogen that causes a wide range of clinical
infections. It is a leading cause of bacteremia and infective endocarditis as well as …

The number of cardiac implantable electronic device (CIED) implantations has increased
over recent years 1, 2 as a result of population growth, increasing life expectancy, adoption …

Background The use of synthetic material for reconstructive vascular surgery was first
reported during the early 1950s. Infection involving vascular graft prostheses is an …

Infectious complications after cardiac implantable electronic device (CIED) implantation are
increasing over time and are associated with substantial mortality and healthcare costs. The …

Background Early performance of the Micra transcatheter pacemaker from the global clinical
trial reported a 99.2% implant success rate, low and stable pacing capture thresholds, and a …

Background: Infection of implanted medical devices has catastrophic consequences. For
cardiac rhythm devices, pre-procedural cefazolin is standard prophylaxis but does not …