A systems view of nitrogen nutrient and metabolite responses in Arabidopsis

EA Vidal, RA Gutiérrez - Current opinion in plant biology, 2008 - Elsevier
Nitrogen (N) is an essential macronutrient available to plants mainly as nitrate in agricultural
soils. Besides its role as a nutrient, inorganic and organic N sources play key roles as …

The primary nitrate response: a multifaceted signalling pathway

A Medici, G Krouk - Journal of experimental botany, 2014 - academic.oup.com
Abstract Nitrate (NO3–) application strongly affects gene expression in plants. This
regulation is thought to be crucial for their adaptation in response to a changing nutritional …

Systems approach identifies TGA1 and TGA4 transcription factors as important regulatory components of the nitrate response of Arabidopsis thaliana roots

JM Alvarez, E Riveras, EA Vidal, DE Gras… - The Plant …, 2014 - Wiley Online Library
Nitrate acts as a potent signal to control global gene expression in A rabidopsis. Using an
integrative bioinformatics approach we identified TGA 1 and TGA 4 as putative regulatory …

Temporal transcriptional logic of dynamic regulatory networks underlying nitrogen signaling and use in plants

K Varala, A Marshall-Colón, J Cirrone… - Proceedings of the …, 2018 - National Acad Sciences
This study exploits time, the relatively unexplored fourth dimension of gene regulatory
networks (GRNs), to learn the temporal transcriptional logic underlying dynamic nitrogen (N) …

VirtualPlant: a software platform to support systems biology research

MS Katari, SD Nowicki, FF Aceituno, D Nero… - Plant …, 2010 - academic.oup.com
Data generation is no longer the limiting factor in advancing biological research. In addition,
data integration, analysis, and interpretation have become key bottlenecks and challenges …

Systems approaches map regulatory networks downstream of the auxin receptor AFB3 in the nitrate response of Arabidopsis thaliana roots

EA Vidal, TC Moyano, E Riveras… - Proceedings of the …, 2013 - National Acad Sciences
Auxin is a key phytohormone regulating central processes in plants. Although the
mechanism by which auxin triggers changes in gene expression is well understood, little is …

Integration of local and systemic signaling pathways for plant N responses

JM Alvarez, EA Vidal, RA Gutiérrez - Current opinion in plant biology, 2012 - Elsevier
Nitrogen (N) is an essential macronutrient and a signal that has profound impacts on plant
growth and development. In order to cope with changing N regimes in the soil, plants have …

Identification of Regulatory and Cargo Proteins of Endosomal and Secretory Pathways in Arabidopsis Thaliana by Proteomic Dissection*[S]

W Heard, J Sklenář, DFA Tome, S Robatzek… - Molecular & Cellular …, 2015 - ASBMB
The cell's endomembranes comprise an intricate, highly dynamic and well-organized
system. In plants, the proteins that regulate function of the various endomembrane …

ConnecTF: A platform to integrate transcription factor–gene interactions and validate regulatory networks

MD Brooks, CL Juang, MS Katari, JM Alvarez… - Plant …, 2021 - academic.oup.com
Deciphering gene regulatory networks (GRNs) is both a promise and challenge of systems
biology. The promise lies in identifying key transcription factors (TFs) that enable an …

Combinatorial interaction network of transcriptomic and phenotypic responses to nitrogen and hormones in the Arabidopsis thaliana root

D Ristova, C Carré, M Pervent, A Medici, GJ Kim… - Science …, 2016 - science.org
Plants form the basis of the food webs that sustain animal life. Exogenous factors, such as
nutrients and sunlight, and endogenous factors, such as hormones, cooperate to control …