Bile acids (BAs) can regulate their own metabolism and transport as well as other key
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …

The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

Cholestatic and non-alcoholic fatty liver disease (NAFLD) share several key
pathophysiological mechanisms which can be targeted by novel therapeutic concepts that …

Primary biliary cholangitis (PBC) is a chronic inflammatory autoimmune cholestatic liver
disease, which when untreated will culminate in end-stage biliary cirrhosis. Diagnosis is …

It is well established that bile acids play important roles in lipid metabolism. In recent
decades, bile acids have also been shown to function as signaling molecules via interacting …

Bile acids facilitate nutrient absorption and are endogenous ligands for nuclear receptors
that regulate lipid and energy metabolism. The brain–gut–liver axis plays an essential role in …

In 1995, the nuclear hormone orphan receptor farnesoid X receptor (FXR, NR1H4) was
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …

Bile acids facilitate intestinal nutrient absorption and biliary cholesterol secretion to maintain
bile acid homeostasis, which is essential for protecting liver and other tissues and cells from …

Background and Aims Cholestatic liver disease is characterized by gut dysbiosis and
excessive toxic hepatic bile acids (BAs). Modification of gut microbiota and repression of BA …