The interferon regulatory factor (IRF) family of transcription factors play a vital role in the
human innate antiviral immune responses with production of interferons (IFNs) as a hallmark …

Macrophages in atherosclerotic patients are notably plastic and heterogeneous. Single-cell
RNA sequencing (Sc RNA-seq) can provide information about all the RNAs in individual …

Senescent cells release a variety of cytokines, proteases, and growth factors collectively
known as the senescence-associated secretory phenotype (SASP). Sustained SASP …

Summary PYHIN proteins AIM2 and IFI204 sense pathogen DNA, while other PYHINs have
been shown to regulate host gene expression through as-yet unclear mechanisms. We …

Monocytic acute myeloid leukemia (AML) responds poorly to current treatments, including
venetoclax-based therapy. We conducted in vivo and in vitro CRISPR-Cas9 library …

The transcriptomic analysis of microarray and RNA-Seq datasets followed our own
bioinformatic pipeline to identify a transcriptional regulatory network of lung cancer. Twenty …

Resistance to targeted therapy remains a major clinical challenge in melanoma. To uncover
resistance mechanisms, we perform single-cell RNA sequencing on fine-needle aspirates …

The hematopoietic interferon-inducible nuclear (HIN) domain of the PYHIN family of proteins
recognizes double-stranded DNA (dsDNA) through different dsDNA-binding modes. These …

Tight regulation of macrophage immune gene expression is required to fight infection
without risking harmful inflammation. The contribution of RNA-binding proteins (RBPs) to …

Chemotherapy-based combinational immunomodulation has been developed to inflame the
“cold” tumor immune microenvironment (TiME) for enhanced triple-negative breast cancer …