The past, present, and future of antibiotics

MA Cook, GD Wright - Science translational medicine, 2022 - science.org
Antibiotics have transformed modern medicine. They are essential for treating infectious
diseases and enable vital therapies and procedures. However, despite this success, their …

Artificial intelligence for natural product drug discovery

MW Mullowney, KR Duncan, SS Elsayed… - Nature Reviews Drug …, 2023 - nature.com
Developments in computational omics technologies have provided new means to access
the hidden diversity of natural products, unearthing new potential for drug discovery. In …

Metal complexes as a promising source for new antibiotics

A Frei, J Zuegg, AG Elliott, M Baker, S Braese… - Chemical …, 2020 - pubs.rsc.org
There is a dire need for new antimicrobial compounds to combat the growing threat of
widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting …

New developments in anti-malarial target candidate and product profiles

JN Burrows, S Duparc, WE Gutteridge… - Malaria journal, 2017 - Springer
A decade of discovery and development of new anti-malarial medicines has led to a
renewed focus on malaria elimination and eradication. Changes in the way new anti …

A review: Pharmacological aspects of metal based 1, 2, 4-triazole derived Schiff bases

W Zafar, SH Sumrra, ZH Chohan - European journal of medicinal chemistry, 2021 - Elsevier
Clinical reports have highlighted the radical increase of antibiotic resistance. As a result,
multidrug resistance has emerged as a serious threat to human health. Many organic …

Antibiotics in the clinical pipeline at the end of 2015

MS Butler, MAT Blaskovich, MA Cooper - The Journal of antibiotics, 2017 - nature.com
There is growing global recognition that the continued emergence of multidrug-resistant
bacteria poses a serious threat to human health. Action plans released by the World Health …

Metal complexes, an untapped source of antibiotic potential?

A Frei - Antibiotics, 2020 - mdpi.com
With the widespread rise of antimicrobial resistance, most traditional sources for new drug
compounds have been explored intensively for new classes of antibiotics. Meanwhile, metal …

Natural products as a source for novel antibiotics

MG Moloney - Trends in pharmacological sciences, 2016 - cell.com
Natural products have historically been of crucial importance in the identification and
development of antibacterial agents. Interest in these systems has waned in recent years …

Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First In Vivo Experiments

A Frei, AG Elliott, A Kan, H Dinh, S Bräse, AE Bruce… - JACS au, 2022 - ACS Publications
There are currently fewer than 10 antifungal drugs in clinical development, but new fungal
strains that are resistant to most current antifungals are spreading rapidly across the world …

Siderophore–antibiotic conjugate design: New drugs for bad bugs?

KH Negash, JKS Norris, JT Hodgkinson - Molecules, 2019 - mdpi.com
Antibiotic resistance is a global health concern and a current threat to modern medicine and
society. New strategies for antibiotic drug design and delivery offer a glimmer of hope in a …