Eukaryotic transcription factors (TFs) are the final integrators of a complex molecular
feedback mechanism that interfaces with the genome, consolidating information for …

Highlights• Dynamic DNA recognition is achieved through a binding mode continuum.•
Multisite binding mechanisms enable functional variability and cross-talks.• Autoinhibition …

Modern microscopy has revealed that core nuclear functions, including transcription,
replication, and heterochromatin formation, occur in spatially restricted clusters. Previous …

Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …

The excessive cosolute densities in the intracellular fluid create a physicochemical condition
called macromolecular crowding (MMC). Intracellular MMC entropically maintains the …

Background As the leading cause of end‐stage liver disease, nonalcoholic fatty liver
disease (NAFLD) is mainly induced by lipid dyshomeostasis. The translation of endogenous …

The pre-tetramerization loop (PTL) of the human tumor suppressor protein p53 is an
intrinsically disordered region (IDR) necessary for the tetramerization process, and its …

Background: Ependymomas are the third most common brain cancer in children and have
no targeted therapies. They are divided into at least 9 major subtypes based on molecular …

Intrinsically disordered regions (IDRs) are critical for cellular function yet often appear to lack
sequence conservation when assessed by multiple sequence alignments. This raises the …

Euryhaline fish experience variable osmotic environments requiring physiological
adjustments to tolerate elevated salinity. Mozambique tilapia (Oreochromis mossambicus) …