The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology

MA Cahill, JA Jazayeri, SM Catalano… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Progesterone receptor membrane component 1 (PGRMC1) is a multi-functional protein with
a heme-binding moiety related to that of cytochrome b 5, which is a putative progesterone …

Membrane associated progesterone receptors: promiscuous proteins with pleiotropic functions–focus on interactions with cytochromes P450

CS Ryu, K Klein, UM Zanger - Frontiers in pharmacology, 2017 - frontiersin.org
Membrane-associated progesterone receptors (MAPR) are a group of four rather small,
partially homologous proteins, which share a similar non-covalent heme-binding domain …

Molecular characterization of membrane steroid receptors in hormone-sensitive cancers

M Masi, M Racchi, C Travelli, E Corsini, E Buoso - Cells, 2021 - mdpi.com
Cancer is one of the most common causes of death worldwide, and its development is a
result of the complex interaction of genetic factors, environmental cues, and aging. Hormone …

Heme-binding protein CYB5D1 is a radial spoke component required for coordinated ciliary beating

L Zhao, H Xie, Y Kang, Y Lin, G Liu… - Proceedings of the …, 2021 - National Acad Sciences
Coordinated beating is crucial for the function of multiple cilia. However, the molecular
mechanism is poorly understood. Here, we characterize a conserved ciliary protein CYB5D1 …

Early eukaryotic origins and metazoan elaboration of MAPR family proteins

E Hehenberger, M Eitel, SAV Fortunato… - Molecular phylogenetics …, 2020 - Elsevier
The membrane-associated progesterone receptor (MAPR) family consists of heme-binding
proteins containing a cytochrome b 5 (cytb 5) domain characterized by the presence of a …

A progesterone receptor membrane component 1 antagonist induces large vesicles independent of progesterone receptor membrane component 1 expression

L Wang-Eckhardt, M Eckhardt - Biological Chemistry, 2020 - degruyter.com
Abstract Treatment of different cell lines with progesterone receptor membrane component 1
(PGRMC1) antagonist AG-205 rapidly induces the formation of large vesicular structures that …

Neudesin as a unique secreted protein with multi-functional roles in neural functions, energy metabolism, and tumorigenesis

H Ohta, I Kimura, M Konishi, N Itoh - Frontiers in molecular …, 2015 - frontiersin.org
Neudesin was originally identified as a secreted protein with neurotrophic activity, and,
thereafter, was also termed neuron-derived neurotrophic factor (NENF) or the candidate …

Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and …

ME Coulter, D Musaev, EM DeGennaro, X Zhang… - Genetics in …, 2020 - nature.com
Purpose The exocyst complex is a conserved protein complex that mediates fusion of
intracellular vesicles to the plasma membrane and is implicated in processes including cell …

Functional validation of metabolic genes that distinguish Gleason 3 from Gleason 4 prostate cancer foci

D Roberto, S Selvarajah, PC Park, D Berman… - The …, 2019 - Wiley Online Library
Background Gleason grade is among the most powerful clinicopathological classification
systems used to assess risk of lethal potential in prostate cancer, yet its biologic basis is …

Microarray data analysis reveals gene expression changes in response to ionizing radiation in MCF7 human breast cancer cells

J Bai, Y Luo, S Zhang - Hereditas, 2020 - Springer
Background The aim of this study was to identify potential therapeutic target genes for breast
cancer (BC) by the investigation of gene expression changes after ionizing radiation (IR) in …