On‐tissue chemical derivatization in mass spectrometry imaging

C Harkin, KW Smith, FL Cruickshank… - Mass spectrometry …, 2022 - Wiley Online Library
Mass spectrometry imaging (MSI) combines molecular and spatial information in a valuable
tool for a wide range of applications. Matrix‐assisted laser desorption/ionization (MALDI) is …

Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development

EG Solon, A Schweitzer, M Stoeckli, B Prideaux - The AAPS journal, 2010 - Springer
Abstract Whole-body autoradiography ((WBA) or quantitative WBA (QWBA)),
microautoradiography (MARG), matrix-assisted laser desorption/ionization mass …

Secondary ion mass spectrometry: characterizing complex samples in two and three dimensions

JS Fletcher, JC Vickerman - Analytical chemistry, 2013 - ACS Publications
Over the last 10 or so years, developments in molecular se-condary ion mass spectrometry
(SIMS) have taken its capability into areas previously only demonstrated in dynamic SIMS …

A concise tutorial review of TOF-SIMS based molecular and cellular imaging

P Massonnet, RMA Heeren - Journal of Analytical Atomic Spectrometry, 2019 - pubs.rsc.org
This concise tutorial review provides a description of the current state of the art in the
application of time-of flight based secondary ion mass spectrometry (TOF-SIMS) in the field …

Low energy ion scattering (LEIS). A practical introduction to its theory, instrumentation, and applications

CV Cushman, P Brüner, J Zakel, GH Major… - Analytical …, 2016 - pubs.rsc.org
Low energy ion scattering (LEIS) probes the elemental composition of the outermost atomic
layer of a material and provides static depth profiles of the outer ca. 10 nm of surfaces. Its …

Enhancing ion yields in time-of-flight-secondary ion mass spectrometry: a comparative study of argon and water cluster primary beams

S Sheraz née Rabbani, I Berrueta Razo… - Analytical …, 2015 - ACS Publications
Following from our previous Letter on this topic, this Article reports a detailed study of time-of-
flight-secondary ion mass spectrometry (TOF-SIMS) positive ion spectra generated from a …

Molecular secondary ion formation under cluster bombardment: A fundamental review

A Wucher - Applied surface science, 2006 - Elsevier
A brief review is given regarding the application of cluster ion beams as desorption probes
in molecular SIMS. The general observation is that the efficiency of secondary ion formation …

Imaging mass spectrometry at cellular length scales

AFM Altelaar, SL Luxembourg, LA McDonnell… - Nature protocols, 2007 - nature.com
Imaging mass spectrometry (IMS) allows the direct investigation of both the identity and the
spatial distribution of the molecular content directly in tissue sections, single cells and many …

Why don't biologists use SIMS?: A critical evaluation of imaging MS

RMA Heeren, LA McDonnell, E Amstalden… - Applied Surface …, 2006 - Elsevier
Secondary ion mass spectrometry is commonly used to study many different types of
complex surfaces. Yet, compared with MALDI and ESI–MS, SIMS has not made a significant …

SIMS—A precursor and partner to contemporary mass spectrometry

JC Vickerman, N Winograd - International Journal of Mass Spectrometry, 2015 - Elsevier
Significant events driving the development of SIMS over the last 50 years are reviewed. The
discussion includes recollections of dynamic and static SIMS from the 1970s, of the …