Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Mitochondria are being recognized as key factors in many unexpected areas of biomedical
science. In addition to their well-known roles in oxidative phosphorylation and metabolism, it …

Activated macrophages undergo metabolic reprogramming, which drives their pro-
inflammatory phenotype, but the mechanistic basis for this remains obscure. Here, we …

The generation of mitochondrial superoxide (O 2−·) by reverse electron transport (RET) at
complex I causes oxidative damage in pathologies such as ischemia reperfusion injury, but …

Increased production of reactive oxygen species (ROS) has long been considered a cause
of aging. However, recent studies have implicated ROS as essential secondary messengers …

Protein-protein interactions govern almost all cellular functions. These complex networks of
stable and transient associations can be mapped by affinity purification mass spectrometry …

Mitochondria contain their own genomes that, unlike nuclear genomes, are inherited only in
the maternal line. Owing to a high mutation rate and low levels of recombination of …

For the vast majority of patients with mitochondrial diseases, only supportive and
symptomatic therapies are available. However, in the last decade, due to extraordinary …

Mitochondria are involved in a variety of cellular functions, including ATP production, amino
acid and lipid biogenesis and breakdown, signalling and apoptosis,,. Mitochondrial …

Mitochondrial respiratory supercomplexes, comprising complexes I, III, and IV, are the
minimal functional units of the electron transport chain. Assembling the individual complexes …