Significance: Aging is a complex trait that is influenced by a combination of genetic and
environmental factors. Although many cellular and physiological changes have been …

Translational geroscience is an interdisciplinary field descended from basic gerontology that
seeks to identify, validate, and clinically apply interventions to maximize healthy, disease …

Altered mitochondrial function is tightly linked to lifespan regulation, but underlying
mechanisms remain unclear. Here, we report the chronological and replicative lifespan …

Targeting aging is the future of twenty-first century preventative medicine. Small molecule
interventions that promote healthy longevity are known, but few are well-developed and …

Different cell types within the body exhibit substantial variation in the average time they live,
ranging from days to the lifetime of the organism. The underlying mechanisms governing the …

To understand the genetic basis and selective forces acting on longevity, it is useful to
examine lifespan variation among closely related species, or ecologically diverse isolates of …

In fluctuating environments, switching between different growth strategies, such as those
affecting cell size and proliferation, can be advantageous to an organism. Trade-offs arise …

Aging is the greatest challenge to humankind worldwide. Aging is associated with a
progressive loss of physiological integrity due to a decline in cellular metabolism and …

Aging varies among individuals due to both genetics and environment, but the underlying
molecular mechanisms remain largely unknown. Using a highly recombined …

Background Mitochondrial function requires numerous genetic interactions between
mitochondrial-and nuclear-encoded genes. While selection for optimal mitonuclear …