Adenosine triphosphate (ATP) is a molecule that on one hand plays a central role in cellular
energetics and which on the other is a ubiquitous signaling molecule when released into the …

Extracellular adenine nucleotides play important roles in cell–cell communication and tissue
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …

P2X receptors are trimeric, non-selective cation channels activated by extracellular ATP. The
P2X 7 receptor subtype is a pharmacological target because of involvement in apoptotic …

The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …

Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

The P2X7 receptor is a trimeric ion channel gated by extracellular adenosine 5′-
triphosphate. The receptor is present on an increasing number of different cells types …

Extracellular adenosine 5′ triphosphate (ATP) is a widespread cell-to-cell signaling
molecule in the brain, where it activates cell surface P2X and P2Y receptors. P2X receptors …

The P2X7 receptor mediates extracellular ATP signaling implicated in the development of
devastating diseases such as chronic pain and cancer. Activation of the P2X7 receptor leads …

P2X7 receptors (Rs) constitute a subclass of ATP-sensitive ionotropic receptors (P2X1-
P2X7). P2X7Rs have many distinguishing features, mostly based on their long intracellular …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …