Competing endogenous RNA (ceRNA) networks in Parkinson's disease: A systematic review

MR Asadi, S Abed, G Kouchakali, F Fattahi… - Frontiers in Cellular …, 2023 - frontiersin.org
Parkinson's disease (PD) is a distinctive clinical syndrome with several causes and clinical
manifestations. Aside from an infectious cause, PD is a rapidly developing neurological …

Paradigm shift required for translational research on the brain

JH Yoon, D Lee, C Lee, E Cho, S Lee… - … & Molecular Medicine, 2024 - nature.com
Biomedical research on the brain has led to many discoveries and developments, such as
understanding human consciousness and the mind and overcoming brain diseases …

Multi‐omic landscaping of human midbrains identifies disease‐relevant molecular targets and pathways in advanced‐stage Parkinson's disease

L Caldi Gomes, A Galhoz, G Jain… - Clinical and …, 2022 - Wiley Online Library
Background Parkinson's disease (PD) is the second most common neurodegenerative
disorder whose prevalence is rapidly increasing worldwide. The molecular mechanisms …

Inflammation and regulatory T cell genes are differentially expressed in peripheral blood mononuclear cells of Parkinson's disease patients

Z Karaaslan, ÖT Kahraman, E Şanlı, HA Ergen… - Scientific reports, 2021 - nature.com
Our aim was to identify the differentially expressed genes (DEGs) in peripheral blood
mononuclear cells (PBMC) of Parkinson's disease (PD) patients and healthy controls by …

Druggable targets for Parkinson's disease: transcriptomics based Mendelian randomization study

Q Lyu, R Chen, Z Qiu, C Wang, R Liu - Scientific Reports, 2024 - nature.com
Parkinson's disease (PD) is a prevalent neurodegenerative disorder. Currently available
drugs for PD, can only relieve the symptoms of PD, but cannot prevent the progression of the …

Early-stage idiopathic Parkinson's disease is associated with reduced circular RNA expression

BJ Whittle, OG Izuogu, H Lowes, D Deen, A Pyle… - npj Parkinson's …, 2024 - nature.com
Neurodegeneration in Parkinson's disease (PD) precedes diagnosis by years. Early
neurodegeneration may be reflected in RNA levels and measurable as a biomarker. Here …

Expression quantitative trait loci (eQTLs) associated with retrotransposons demonstrate their modulatory effect on the transcriptome

S Koks, AL Pfaff, VJ Bubb, JP Quinn - International Journal of Molecular …, 2021 - mdpi.com
Transposable elements (TEs) are repetitive elements that belong to a variety of functional
classes and have an important role in shaping genome evolution. Around 50% of the human …

Longitudinal intronic RNA-Seq analysis of Parkinson's disease patients reveals disease-specific nascent transcription

S Koks, AL Pfaff, VJ Bubb… - Experimental Biology and …, 2022 - journals.sagepub.com
Transcriptomic studies usually focus on either gene or exon-based annotations, and only
limited experiments have reported changes in reads mapping to introns. The analysis of …

Network Analysis Performed on Transcriptomes of Parkinson's Disease Patients Reveals Dysfunction in Protein Translation

S D'Angiolini, M Lui, E Mazzon, M Calabrò - International Journal of …, 2024 - mdpi.com
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the
progressive degeneration of dopaminergic neurons in the substantia nigra region of the …

Integrative analysis of gene expression profiles of substantia nigra identifies potential diagnosis biomarkers in Parkinson's disease

J Huang, B Li, H Wei, C Li, C Liu, H Mi, S Chen - Scientific Reports, 2024 - nature.com
Parkinson's disease (PD) is a progressive neurodegenerative disease whose etiology is
attributed to development of Lewy bodies and degeneration of dopaminergic neurons in the …