Pseudomonas aeruginosa is a Gram-negative bacterial pathogen that is a common cause of
nosocomial infections, particularly pneumonia, infection in immunocompromised hosts, and …

Ventilator-associated pneumonia (VAP) is one of the most frequent ICU-acquired infections.
Reported incidences vary widely from 5 to 40% depending on the setting and diagnostic …

Infections with Pseudomonas aeruginosa have become a real concern in hospital-acquired
infections, especially in critically ill and immunocompromised patients. The major problem …

Bloodstream infection (BSI) is defined by positive blood cultures in a patient with systemic
signs of infection and may be either secondary to a documented source or primary—that is …

Abstract The Working Party makes more than 100 tabulated recommendations in
antimicrobial prescribing for the treatment of infections caused by multidrug-resistant (MDR) …

The burden of multidrug resistance in Gram-negative bacilli (GNB) now represents a daily
issue for the management of antimicrobial therapy in intensive care unit (ICU) patients. In …

The rapid emergence and dissemination of antimicrobial-resistant microorganisms in ICUs
worldwide constitute a problem of crisis dimensions. The root causes of this problem are …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Sepsis is a common and lethal syndrome: although outcomes have improved, mortality
remains high. No specific anti-sepsis treatments exist; as such, management of patients …

The nitrile group is an important functional group widely found in both pharmaceutical
agents and natural products. More than 30 nitrile-containing pharmaceuticals have been …