The beta2‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?

M Hostrup, J Onslev - The Journal of Physiology, 2022 - Wiley Online Library
Abstract Treatment of obesity with repurposed or novel drugs is an expanding research field.
One approach is to target beta2‐adrenergic receptors because they regulate the metabolism …

Annual banned‐substance review: Analytical approaches in human sports drug testing 2019/2020

M Thevis, T Kuuranne, H Geyer - Drug testing and analysis, 2021 - Wiley Online Library
Analytical chemistry‐based research in sports drug testing has been a dynamic endeavor for
several decades, with technology‐driven innovations continuously contributing to significant …

Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells

J Meister, DBJ Bone, JR Knudsen, LF Barella… - Nature …, 2022 - nature.com
Activation of the sympathetic nervous system causes pronounced metabolic changes that
are mediated by multiple adrenergic receptor subtypes. Systemic treatment with β2 …

Anti-Doping policy, therapeutic use exemption and medication use in athletes with asthma: a narrative review and critical appraisal of current regulations

H Allen, SH Backhouse, JH Hull, OJ Price - Sports Medicine, 2019 - Springer
Asthma is prevalent in athletes and when untreated can impact both respiratory health and
sports performance. Pharmacological inhaler therapy currently forms the mainstay of …

Anabolic and lipolytic actions of beta2‐agonists in humans and antidoping challenges

M Hostrup, GA Jacobson, S Jessen… - Drug Testing and …, 2020 - Wiley Online Library
Inhaled beta2‐adrenoceptor agonists (beta2‐agonists) are among the most used
substances in competitive sports. The 2020 Prohibited List issued by the World Anti‐Doping …

Asthma and exercise‐induced bronchoconstriction in athletes: diagnosis, treatment, and anti‐doping challenges

M Hostrup, ESH Hansen… - … journal of medicine …, 2024 - Wiley Online Library
Athletes often experience lower airway dysfunction, such as asthma and exercise‐induced
bronchoconstriction (EIB), which affects more than half the athletes in some sports, not least …

Beta2‐adrenoceptor agonist salbutamol increases protein turnover rates and alters signalling in skeletal muscle after resistance exercise in young men

M Hostrup, S Reitelseder, S Jessen… - The Journal of …, 2018 - Wiley Online Library
Key points Animal models have shown that beta2‐adrenoceptor stimulation increases
protein synthesis and attenuates breakdown processes in skeletal muscle. Thus, the beta2 …

Can β2-agonists have an ergogenic effect on strength, sprint or power performance? Systematic review and meta-analysis of RCTs

A Riiser, T Stensrud, J Stang… - British journal of sports …, 2020 - bjsm.bmj.com
Objectives We aimed to examine the effect of β2-agonists on anaerobic performance in
healthy non-asthmatic subjects. Design Systematic review and meta-analysis. Eligibility …

Beta2‐adrenergic agonist clenbuterol increases energy expenditure and fat oxidation, and induces mTOR phosphorylation in skeletal muscle of young healthy men

S Jessen, SA Solheim, GA Jacobson… - Drug testing and …, 2020 - Wiley Online Library
Clenbuterol is a beta2‐adrenoceptor agonist marketed as an asthma reliever but is not
approved for human use in most countries due to concerns of adverse cardiac effects. Given …

An abductive inference approach to assess the performance-enhancing effects of drugs included on the World Anti-Doping Agency prohibited list

A Breenfeldt Andersen, GA Jacobson, J Bejder… - Sports Medicine, 2021 - Springer
Some have questioned the evidence for performance-enhancing effects of several
substances included on the World Anti-Doping Agency's Prohibited List due to the divergent …