It has been 50 years since Francis Fontan pioneered the operation that today bears his
name. Initially designed for patients with tricuspid atresia, this procedure is now offered for a …

Background and Purpose: The diverse causes of right-sided heart failure (RHF) include,
among others, primary cardiomyopathies with right ventricular (RV) involvement, RV …

The past 60 years have brought remarkable advancements in the diagnosis and treatment of
congenital heart disease (CHD). Early diagnosis and improvements in cardiac surgery and …

Universally fatal only 4 decades ago, the progress in the 3-stage palliation of hypoplastic left
heart syndrome and related single right ventricular lesions has drastically improved the …

Heart failure (HF) is a complex clinical syndrome resulting from diverse primary and
secondary causes and shared pathways of disease progression, correlating with substantial …

Therapies developed for adult patients with heart failure have been shown to be ineffective
in pediatric clinical trials, leading to the recognition that new pediatric-specific therapies for …

Optimizing nutritional intake has been targeted as a key component of the National Pediatric
Cardiology Quality Improvement Collaborative. This initiative has enabled the development …

Rationale: Patients with single ventricle physiology are at high risk of mortality resulting from
ventricular dysfunction. The preliminary results of the phase 1 trial showed that cardiosphere …

An abundance of data has provided insight into the mechanisms underlying the
development of left ventricular (LV) hypertrophy and its progression to LV failure. In contrast …

Cardiac arrest occurs at a higher rate in children with heart disease than in healthy children.
Pediatric basic life support and advanced life support guidelines focus on delivering high …