Eukaryotic cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial
respiratory chain. COX is a multimeric enzyme formed by subunits of dual genetic origin …

Copper is required within the mitochondrion for the function of two metalloenzymes,
cytochrome c oxidase (CcO) and superoxide dismutase (Sod1). Copper metallation of these …

Metals are essential elements of all living organisms. Among them, copper is required for a
multiplicity of functions including mitochondrial oxidative phosphorylation and protection …

Cytochrome c-oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain,
plays a key role in the regulation of aerobic production of energy. Biogenesis of eukaryotic …

Mitochondria maintain genome and translation machinery to synthesize a small subset of
subunits of the oxidative phosphorylation system. To build up functional enzymes, these …

The components of the mitochondrial proteome represent a mosaic of dual genetic origin:
while most mitochondrial proteins are encoded by nuclear genes and imported into the …

Copper is an essential but potentially harmful trace element required in many enzymatic
processes involving redox chemistry. Cellular copper homeostasis in mammals is …

Cytochrome c oxidase is the terminal complex of eukaryotic oxidative phosphorylation in
mitochondria. This process couples the reduction of electron carriers during metabolism to …

For production of proteins that are encoded by the mitochondrial genome, mitochondria rely
on their own mitochondrial translation system, with the mitoribosome as its central …

The genome of mitochondria encodes a small number of very hydrophobic polypeptides that
are inserted into the inner membrane in a cotranslational reaction. The molecular process by …