This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

Over the past decade, numerous studies have shown that increased aortic stiffness is
associated with major cardiovascular disease end points, including heart disease, stroke …

Hypertension is associated with altered structure of the resistance vessels, a process known
as remodeling. This review summarizes current concepts concerning the structure of a …

The diameter of resistance arteries has a profound effect on the distribution of microvascular
blood flow and the control of systemic blood pressure. Here, we review mechanisms that …

The adequate and efficient functioning of the microcirculation requires not only numerous
vessels providing a large surface area for transport but also a structure that provides short …

Loss of cognitive function and hypertension are two common conditions in the elderly and
both significantly contribute to loss of personal independency. Microvascular brain damage …

Although considered by many as the gold standard clinical measure of arterial stiffness,
carotid-to-femoral pulse wave velocity (cf-PWV) averages material and geometric properties …

Carotid-femoral pulse wave velocity (PWV), an index of large artery stiffness, is a good proxy
of arterial aging and also an independent marker of cardiovascular disease. A consistently …

Blood flow regulation by small arteries and arterioles includes adaptation of both vascular
tone and structure. It is becoming clear that tone and remodeling of resistance vessels are …