Losing, preserving, and restoring vision from neurodegeneration in the eye

D Kerschensteiner - Current Biology, 2023 - cell.com
The retina is a part of the brain that sits at the back of the eye, looking out onto the world. The
first neurons of the retina are the rod and cone photoreceptors, which convert changes in …

[HTML][HTML] Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: Interference by cholinesterase inhibitors

K Schwab, D Lauer, M Magbagbeolu, F Theuring… - Brain Research …, 2024 - Elsevier
In clinical trials for Alzheimer's disease (AD), hydromethylthionine mesylate (HMTM) showed
reduced efficacy when administered as an add-on to symptomatic treatments, while it …

Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

X Luo, N Zhang, Y Liu, B Du, X Wang, T Zhao… - Science China Life …, 2024 - Springer
Abstract The coronavirus disease 2019 (COVID-19) outbreak caused by the severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) developed into a global health …

Nanoscaled RIM clustering at presynaptic active zones revealed by endogenous tagging

A Mrestani, S Dannhäuser, M Pauli… - Life Science …, 2023 - life-science-alliance.org
Chemical synaptic transmission involves neurotransmitter release from presynaptic active
zones (AZs). The AZ protein Rab-3-interacting molecule (RIM) is important for normal Ca2+ …

Versatile Endogenous Editing of GluRIIA in Drosophila melanogaster

CJ Beckers, A Mrestani, F Komma, S Dannhäuser - Cells, 2024 - mdpi.com
Glutamate receptors at the postsynaptic side translate neurotransmitter release from
presynapses into postsynaptic excitation. They play a role in many forms of synaptic …

Endogenous tagging of Unc-13 reveals nanoscale reorganization at active zones during presynaptic homeostatic potentiation

S Dannhäuser, A Mrestani, F Gundelach… - Frontiers in Cellular …, 2022 - frontiersin.org
Introduction Neurotransmitter release at presynaptic active zones (AZs) requires concerted
protein interactions within a dense 3D nano-hemisphere. Among the complex protein …

Ultrastructural analysis of wild-type and RIM1α knockout active zones in a large cortical synapse

K Lichter, MM Paul, M Pauli, S Schoch… - Cell Reports, 2022 - cell.com
Rab3A-interacting molecule (RIM) is crucial for fast Ca 2+-triggered synaptic vesicle (SV)
release in presynaptic active zones (AZs). We investigated hippocampal giant mossy fiber …

Single-Molecule Localization Microscopy of Presynaptic Active Zones in Drosophila melanogaster after Rapid Cryofixation

A Mrestani, K Lichter, AL Sirén, M Heckmann… - International Journal of …, 2023 - mdpi.com
Single-molecule localization microscopy (SMLM) greatly advances structural studies of
diverse biological tissues. For example, presynaptic active zone (AZ) nanotopology is …

Nanoscaled RIM clustering at presynaptic active zones revealed by endogenous tagging

T Langenhan, M Heckmann, MM Paul - 2023 - life-science-alliance.org
Neurotransmitter release at presynaptic active zones (AZs) is fundamental for information
processing within the nervous system (Südhof, 2012; Neher & Brose, 2018; Emperador …

Die Ultrastruktur von Aktiven Zonen in hippocampalen Moosfaserboutons

K Lichter - 2023 - opus.bibliothek.uni-wuerzburg.de
In Nervensystemen bedürfen Informationsweitergabe und Gedächtnisformation eines
präzisen Zusammenspiels von Synapsen in Zeit und Raum. Synaptische Transmission …