This manuscript reviews the clinical evidence regarding single-dose intravenous (IV)
administration of the novel glutamatergic modulator racemic (R, S)-ketamine (hereafter …

Impaired cognition is often overlooked in the clinical management of depression, despite its
association with poor psychosocial functioning and reduced clinical engagement. There is …

The emerging roles of ketamine and esketamine as effective rapid-acting antidepressants
hold promise for patients suffering from treatment-resistant depression and/or major …

Background The association between impaired social cognition and bipolar disorder (BD) is
well established. However, to our knowledge, there has not been a recent systematic review …

Background We investigated the effects of liraglutide, a glucagon-like peptide-1 (GLP-1)
agonist, on a depression-like phenotype in mice exposed to chronic unpredictable stress …

Background Unipolar treatment-resistant depression (MDD-TRD) is associated with
neurocognitive impairment. Ketamine, an emerging treatment for MDD-TRD, may have …

Objective To evaluate the effects of ketamine treatment on depression and suicidal ideation
in treatment resistant depression (TRD) and to determine whether they are influenced by …

Background Ketamine and its enantiomer have rapid and robust effects on depressive
symptom and suicidal ideation. Little is known about their cognitive effects in adolescents …

Background Ketamine has rapid and robust antidepressant effects in depression, while its
effects on cognitive measures are less clearly understood. This aim of the study herein is to …

Introduction Cognitive impairment is a core feature of bipolar disorder (BD) that impedes
recovery by preventing the return to optimal socio-occupational functioning and reducing …