Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most
evolutionarily conserved cellular quality control mechanisms. Although NMD was first found …

Nonsense-mediated mRNA decay (NMD) is a quality control pathway in eukaryotes that
continuously monitors mRNA transcripts to ensure truncated polypeptides are not produced …

Recent findings suggest that the ribosome itself modulates gene expression. However,
whether ribosomes change composition across cell types or control cell fate remains …

The nonsense‐mediated mRNA decay pathway selects and degrades its targets using a
dense network of RNA‐protein and protein–protein interactions. Together, these interactions …

Highlights•Collided ribosomes form a unique disomal interface and are a hallmark of
slow/stalled translation.•Ribosome ubiquitination is triggered by ribosome collisions …

Upf1, Upf2, and Upf3, the central regulators of nonsense-mediated mRNA decay (NMD),
appear to exercise their NMD functions while bound to elongating ribosomes, and evidence …

Faulty mRNAs with a premature stop codon (PTC) are recognized and degraded by
nonsense-mediated mRNA decay (NMD). Recognition of a nonsense mRNA depends on …

Up-frameshift protein 1 (UPF1) plays the role of a vital controller for transcripts, ready to react
in the event of an incorrect translation mechanism. It is well known as one of the key …

Nonsense-mediated RNA decay (NMD) is the prototype example of a whole family of RNA
decay pathways that unfold around a common central effector protein called UPF1. While …

Chemical probing methods are crucial to our understanding of the structure and function of
RNA molecules. The majority of chemical methods used to probe RNA structure report on …