Sodium bicarbonate (NaHCO3) has been recognized as a possible therapy to target chronic
kidney disease (CKD) progression. Several small clinical trials have demonstrated that …

Stimulation of the inflammatory reflex (IR) is a promising strategy to treat systemic
inflammatory disorders. However, this strategy is hindered by the cost and side effects of …

Background: In patients with chronic kidney disease (CKD), impaired kidney acid excretion
leads to the onset of metabolic acidosis (MA). However, the evidence is not yet conclusive …

Patients with chronic kidney disease (CKD) continue to produce endogenous acids but have
a reduction in net acid excretion, resulting in a primary decrease in serum bicarbonate …

Chronic kidney disease (CKD) is characterized by progressive reduction in kidney function
and treatments aiming at stabilizing or slowing its progression may avoid or delay the …

Stimulation of the inflammatory reflex (IR) is a promising strategy for treating systemic
inflammatory disorders. Recent studies suggest oral sodium bicarbonate (NaHCO3) as a …

Sodium bicarbonate (NaHCO3) is commonly utilized as a therapeutic to treat metabolic
acidosis in people with chronic kidney disease (CKD). While increased dietary sodium …

The presence of tubular casts within the kidney serves as an important feature when
assessing the degree of renal injury. Quantification of renal tubular casts has been …

Much research now indicates that vagal nerve stimulation results in a systemic reduction in
inflammatory cytokine production and an increase in anti-inflammatory cell populations that …

Impairments in insulin sensitivity can occur in patients with chronic kidney disease (CKD).
Correction of metabolic acidosis has been associated with improved insulin sensitivity in …