Current research on human aging has largely been guided by the milestone paper
“hallmarks of aging,” which were first proposed in the seminal 2013 paper by Lopez‐Otin et …

Sirtuins, which are NAD+-dependent class III histone deacetylases, are involved in various
biological processes, including DNA damage repair, immune inflammation, oxidative stress …

As a common emerging environmental pollutant, microplastics (MPs) have been detected in
a variety of environmental media and human bodies. The potential toxic effects and …

Mitochondria are dynamic organelles that play a crucial role in numerous cellular activities.
Their primary function is to convert the energy stored in nutrients into adenosine …

Excessive intake of fat and fructose in Western diets has been confirmed to induce renal
lipotoxicity, thereby driving the progression of chronic kidney disease (CKD). This study was …

Podocytes are the key target cells for injury across the spectrum of primary and secondary
proteinuric kidney disorders, which account for up to 90% of cases of kidney failure …

Acute kidney injury (AKI) is a systemic clinical syndrome increasing morbidity and mortality
worldwide in recent years. Renal tubular epithelial cells (TECs) death caused by …

Dent disease type 1 is a rare X-linked recessive inherited renal disorder affecting mainly
young males, generally leading to end-stage renal failure and for which there is no cure. It is …

Renal diseases are a serious public health issue worldwide, and existing treatments are
often limited in their effectiveness. Vitamin D (Vit. D) is known for its pleiotropic effects on …

线粒体在维持肾脏固有细胞正常功能中发挥了重要作用, 糖尿病导致的高血糖状态,
可引起线粒体稳态失衡和氧化应激反应, 进而介导肾脏固有细胞损伤, 参与糖尿病肾病的发生和 …