Lymphopenia caused by virus infections and the mechanisms beyond
Z Guo, Z Zhang, M Prajapati, Y Li - Viruses, 2021 - mdpi.com
Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the
blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune …
blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune …
Natural killer cells and their exosomes in viral infections and related therapeutic approaches: where are we?
MH Razizadeh, A Zafarani… - Cell Communication and …, 2023 - Springer
Innate immunity is the first line of the host immune system to fight against infections. Natural
killer cells are the innate immunity lymphocytes responsible for fighting against virus …
killer cells are the innate immunity lymphocytes responsible for fighting against virus …
Ebola virus binding to Tim-1 on T lymphocytes induces a cytokine storm
Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response
that is highlighted by a burst in the production of inflammatory mediators known as a …
that is highlighted by a burst in the production of inflammatory mediators known as a …
Antibody-dependent enhancement of Ebola virus infection by human antibodies isolated from survivors
Some monoclonal antibodies (mAbs) recovered from survivors of filovirus infections can
protect against infection. It is currently unknown whether natural infection also induces some …
protect against infection. It is currently unknown whether natural infection also induces some …
Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses
Specific host pathways that may be targeted therapeutically to inhibit the replication of Ebola
virus (EBOV) and other emerging viruses remain incompletely defined. A screen of 200,000 …
virus (EBOV) and other emerging viruses remain incompletely defined. A screen of 200,000 …
The host E3-ubiquitin ligase TRIM6 ubiquitinates the Ebola virus VP35 protein and promotes virus replication
Ebola virus (EBOV), a member of the Filoviridae family, is a highly pathogenic virus that
causes severe hemorrhagic fever in humans and is responsible for epidemics throughout …
causes severe hemorrhagic fever in humans and is responsible for epidemics throughout …
Innate immune responses of bat and human cells to filoviruses: commonalities and distinctions
IV Kuzmin, TM Schwarz, PA Ilinykh, I Jordan… - Journal of …, 2017 - Am Soc Microbiol
ABSTRACT Marburg (MARV) and Ebola (EBOV) viruses are zoonotic pathogens that cause
severe hemorrhagic fever in humans. The natural reservoir of MARV is the Egyptian rousette …
severe hemorrhagic fever in humans. The natural reservoir of MARV is the Egyptian rousette …
Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection
M Iampietro, P Younan, A Nishida, M Dutta… - PLoS …, 2017 - journals.plos.org
Fatal outcomes of Ebola virus (EBOV) infections are typically preceded by a 'sepsis-
like'syndrome and lymphopenia despite T cells being resistant to Ebola infection. The …
like'syndrome and lymphopenia despite T cells being resistant to Ebola infection. The …
Pathogenicity and Virulence of Ebolaviruses with Species-and Variant-specificity
Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus,
causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%. While …
causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%. While …
Immune responses to viruses
SN Mueller, BT Rouse - Clinical Immunology, 2009 - pmc.ncbi.nlm.nih.gov
Viruses as obligate intracellular parasites require their host to replicate them and to facilitate
their spread to others. In humans, viral infections are rarely lethal, even if they are highly …
their spread to others. In humans, viral infections are rarely lethal, even if they are highly …