Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with …

Pulmonary endothelial cells (ECs) are an essential component of the gas exchange
machinery of the lung alveolus. Despite this, the extent and function of lung EC …

Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a
hallmark of solid tumors. This process is driven by an imbalance between pro-and anti …

Aims A better understanding of the pathways that regulate regeneration of the coronary
vasculature is of fundamental importance for the advancement of strategies to treat patients …

Four decades ago, angiogenesis was recognized as a therapeutic target for blocking cancer
growth. Because of its importance, VEGF has been at the center stage of antiangiogenic …

Bone morphogenetic proteins (BMPs) and their receptors, known to be essential regulators
of embryonic patterning and organogenesis, are also critical for the regulation of …

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-
β) family that signal via type I and type II serine/threonine kinase receptors and intracellular …

Notch signaling is a highly conserved signal transduction pathway that regulates stem cell
maintenance and differentiation in several organ systems. Upon activation, the Notch …