Microorganisms produce a wealth of structurally diverse specialized metabolites with a
remarkable range of biological activities and a wide variety of applications in medicine and …

Covering: 2013 to June 2018 Heterologous expression of natural product biosynthetic
pathways is of increasing interest in microbial biotechnology, drug discovery and …

Natural products (NPs) are critical sources of drug molecules for decades. About two-thirds
of natural antibiotics are produced by Streptomyces. Streptomyces have a large number of …

Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

Actinomycetes are one of the most valuable sources of natural products with industrial and
medicinal importance. After more than half a century of exploitation, it has become …

Actinomycetes continue to be important sources for the discovery of secondary metabolites
for applications in human medicine, animal health, and crop protection. With the maturation …

We report a new Streptomyces species named S. formicae that was isolated from the African
fungus-growing plant-ant Tetraponera penzigi and show that it produces novel pentacyclic …

Covering: up to 2015 Multienzyme polyketide synthases (PKSs) are molecular-scale
assembly lines which construct complex natural products in bacteria. The underlying …

Heterologous gene expression is one of the main strategies used to access the full
biosynthetic potential of actinomycetes, as well as to study the metabolic pathways of natural …

Streptomyces are attractive microbial cell factories that have industrial capability to produce
a wide array of bioactive secondary metabolites. However, the genetic potential of the …