The growth and dynamics of multicellular tissues involve tightly regulated and coordinated
morphogenetic cell behaviors, such as shape changes, movement, and division, which are …

Multiscale computational modeling aims to connect the complex networks of effects at
different length and/or time scales. For example, these networks often include intracellular …

Stem cell maintenance in multilayered shoot apical meristems (SAMs) of plants requires
strict regulation of cell growth and division. Exactly how the complex milieu of chemical and …

Morphogenetic programs coordinate cell signaling and mechanical interactions to shape
organs. In systems and synthetic biology, a key challenge is determining optimal cellular …

How a developing organ robustly coordinates the cellular mechanics and growth to reach a
final size and shape remains poorly understood. Through iterations between experiments …

Organogenesis is a complex process that relies on the integration of a diverse set of inputs
to control multiple downstream cellular processes forming a bow-tie network. Second …

Epithelial tissues function to maintain physical barriers and protect organs against
pathogens, microbes, and toxins. Tissue-wide coordination of mechanical stiffness requires …